代谢综合征,甲状腺功能障碍和心血管风险:邪恶的三重画
Alessandro Pingitore1, Melania Gaggini1, Francesca Mastorci1
1Clinical Physiology Institute, CNR, 56124 Pisa, Italy.
International journal of molecular sciences
|October 16, 2024
概括
代谢综合征 (MetS) 和甲状腺功能障碍密切相关,影响心血管风险. 治疗甲状腺疾病患者的甲状腺问题对于更好的健康结果和管理代谢和心脏健康至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 心血管医学 心血管医学
背景情况:
- 甲状腺激素 (THs) 是葡萄糖和脂质代谢以及血液动力学功能的关键调节者.
- 甲状腺功能障碍和代谢综合征 (MetS) 之间存在复杂的双向关系.
- 甲状腺功能障碍和甲状腺功能障碍都与炎症和氧化应激有关,加剧心血管 (CV) 风险.
研究的目的:
- 探索甲状腺功能障碍,METS和心血管风险之间的复杂联系.
- 为了突出这一三位一体的分子和临床含义.
- 强调评估和管理甲状腺功能的重要性.
主要方法:
- 审查关于甲状腺激素,代谢综合征和心血管健康之间的相互作用的现有文献.
- 对将甲状腺功能与代谢调节和心血管风险因素联系起来的分子机制的分析.
- 关于甲状腺状况与MetS组件之间的关联的临床观察.
主要成果:
- 甲状腺功能障碍加剧了胰岛素耐药性,脂质障碍 (LDL-C,VLDL-C,甘油三酸的升高) 和内皮功能障碍.
- THs影响白色和棕色脂肪组织,影响代谢健康.
- 甲状腺系统与甲状腺功能障碍之间的关联导致一般人群和心力衰竭或心肌梗塞患者心血管事件增加.
结论:
- 甲状腺功能障碍和甲状腺功能障碍经常同时存在,因此需要对甲状腺功能进行评估.
- 维护类甲状腺症对于管理METS和降低心血管风险很重要.
- 需要进一步的研究,特别是在治疗METS患者的亚临床甲状腺功能障碍方面.
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