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Updated: Jun 10, 2025

Fabrication of 3D Cardiac Microtissue Arrays using Human iPSC-Derived Cardiomyocytes, Cardiac Fibroblasts, and Endothelial Cells
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基于三维iPSC的体外心脏模型用于生物医学和制药研究应用

Simona Bufi1, Rosaria Santoro1,2

  • 1Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino-IRCCS, 20138 Milan, Italy.

International journal of molecular sciences
|October 16, 2024
PubMed
概括

三维 (3D) 诱导多能干细胞 (iPSC) 模型为研究心血管疾病提供了一个强大的平台. 这些针对特定患者的模型推进了个性化医疗和治疗复杂心脏病的药物开发.

关键词:
这是心脏病,心脏病.心肌病性心脏病 - 心肌病性心脏病工程心脏组织的工程心脏组织.在体外建模 in vitro 建模微组织微组织.这是一种有机物质的有机物质.

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EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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