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Updated: Jun 10, 2025

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles
06:58

Evaluation of LC3-II Release via Extracellular Vesicles in Relation to the Accumulation of Intracellular LC3-positive Vesicles

Published on: October 18, 2024

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小分子通过与突变ATXN3和LC3的相互作用诱导扩展型多重胺蛋白的自降解

Te-Hsien Lin1, Wan-Ling Chen1, Shao-Fan Hsu2

  • 1Department of Neurology, Chang-Gung Memorial Hospital, Chang-Gung University College of Medicine, Taoyuan 33302, Taiwan.

International journal of molecular sciences
|October 16, 2024
PubMed
概括

新的化合物NC009-1, -2, -6和LM-031抑制了多重氨酸的聚合,并在脊髓小脑动脉动脉模型中促进神经元的存活. 这些化合物作为自细胞结合化合物 (ATTEC),增强有毒蛋白质的清除.

关键词:
在ATXN3中使用.LC3 LC3 LC3 的意思是什么意思在 SCA3 疗法中,SCA3 疗法是:自胞体结合的自胞体结合聚氨酸多重蛋白质胺的方法基于金星的BiFC.

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