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耐力运动训练对肠道微生物群和ER压力的影响

Eun Ji Yoon¹, So Rok Lee², Beulah Favour Ortutu²

¹Research Center for Microbiome-Brain Disorders, Chungnam University, Daejeon 34134, Republic of Korea.

International journal of molecular sciences

|October 16, 2024

概括

长期的耐力运动通过改变炎症和内分泌网膜 (ER) 压力影响肠道. 运动促进肠道完整性,并改变肠道微生物群,影响脂肪酸代谢.

科学领域:

运动生理学运动生理学
胃肠病学胃肠病学
微生物组研究微生物组研究

背景情况:

定期炼提供健康益处,但其对肠道环境的影响尚未完全理解.
众所周知,耐力运动会影响各种生理系统,但它对肠道炎症和压力的具体影响需要详细研究.

研究的目的:

研究长期耐力运动对调节肠道炎症和内质网膜 (ER) 压力的影响.
探索运动引起的肠道完整性标记物和肠道微生物组的组成和功能的变化.

主要方法:

雄性Sprague-Dawley大鼠接受了为期六个月的跑步机训练,与静止控制.
结肠和肝脏组织分析了与炎症和ER压力相关的基因和蛋白质表达.
评估了肠道完整性标志物 (MUC2,Occludin,Claudin-2) 和肠道微生物群组成 (α-多样性,特定种群).

主要成果:

耐力运动在结肠中增加了IL-6mRNA,并在肝脏和结肠中激活了ER压力诱导的生存途径 (BiP,p-eIF2α).
肠道完整性得到增强,体现了运动组中MUC2,奥克卢丁和克劳丁-2表达的增加.
在微生物群α-多样性和BiP表达之间观察到一种积极的相关性,其中增加了Desulfovibrio C21 c20种群,并增强了与脂肪酸相关的微生物功能.

结论:

长时间的耐力运动显著改变结肠环境,影响炎症和ER压力.
运动增强了肠道屏障功能,并重塑了肠道微生物群,可能改善脂肪酸代谢.
这些适应表明耐力运动,肠道健康和微生物社区动态之间的复杂相互作用.

关键词:

细胞内膜网膜的压力应激耐力运动是一种耐力运动.我们的肠道微生物组.这是一种炎症炎症炎症炎症.紧密的交叉路口紧密的连接

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