孕产妇的肥胖会改变胎盘和带血的氧化压力,一个横截面研究
Thanyawan Jantape1, Kiattisak Kongwattanakul2, Silvia M Arribas3
1Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
International journal of molecular sciences
|October 16, 2024
概括
孕产妇的肥胖会增加胎盘和新生儿的氧化压力,影响胎儿的发育. 这项研究发现,在孕妇因孕产妇肥胖而复杂的怀孕中,氧化标志物升高和抗氧化防御能力发生变化.
科学领域:
- 生殖生物学 生殖生物学
- 代谢健康 代谢健康
- 围产儿医学 围产儿医学
背景情况:
- 孕产妇肥胖与不良妊娠结果和后代的长期代谢编程有关.
- 在孕产妇肥胖症中,胎盘氧化状况受损可能会导致这些负面影响.
研究的目的:
- 调查孕产妇肥胖对孕产妇和带血氧化状态的影响.
- 在孕产妇肥胖的背景下评估胎盘氧化适应.
主要方法:
- 从肥胖女性 (BMI ≥25 kg/m2) 和瘦女性 (BMI <23 kg/m2) 的母体和带血和胎盘组织进行比较.
- 评估了营养含量,氧化应激标志物 (MDA,蛋白碳基) 和抗氧化活性 (SOD,催化酶).
- 评估了SOD2,catalase,UCP2和Nrf2的胎盘蛋白质表达,使用西方斑点分析.
主要成果:
- 孕产妇肥胖症显示孕产妇血催化酶活性增加,并趋向于更高的MDA和蛋白质碳酸水平.
- 在孕产妇肥胖组的带血中,甘油三,蛋白碳基和催化酶活性升高.
- 胎盘分析显示,SOD2,catalase和Nrf2的表达减少,但在孕产妇肥胖时,UCP2的表达增加.
结论:
- 孕产妇肥胖与严重的胎盘和胎儿氧化压力有关.
- 胎盘抗氧化防御发生变化,SOD2,催化酶和Nrf2减少,但UCP2增加.
- 研究结果强调了孕妇肥胖对妊娠中氧化状态和胎儿发育的有害影响.
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