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Confocal Fluorescence Microscopy01:16

Confocal Fluorescence Microscopy

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Confocal microscopy is an advanced microscopic technique. The prime advantage of the confocal microscope over other microscopy techniques is its ability to block the out-of-focus light from the illuminated samples using pinholes. It is widely used with fluorescence optics to obtain high-resolution, sharp contrast images. Unlike optical microscopes, confocal microscopes use a focused beam of light laser to scan the entire sample surface at different z-planes. These microscopes are, therefore,...
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相关实验视频

Updated: Jun 10, 2025

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
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Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

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紧型激光诱导光探测器,具有可调节的激光焦点,用于多种用途.

Zihe Xu1,2, Xi Chen3, Fangwu Liu1

  • 1Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China.

Sensors (Basel, Switzerland)
|October 16, 2024
PubMed
概括

开发了一种新的紧型激光诱导光 (LIF) 探测器,用于敏感的分子检测. 这种小型化系统在各种分析平台 (包括基于太空的系统) 上具有广泛的适用性.

关键词:
可以调节的可调节.这种表现的表现是表现的光效应.这是一个手持式手持式手持式手持式.激光诱导的光是一种激光诱导的光.检测的检测极限.

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相关实验视频

Last Updated: Jun 10, 2025

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科学领域:

  • 分析化学 分析化学
  • 生物光子学 生物光子学
  • 仪器仪表工程 仪器仪表工程

背景情况:

  • 在各个研究领域,对微型激光诱导光 (LIF) 检测系统的需求日益增加.
  • 需要针对毛细血管,PCR管和微流体芯片等不同目标进行适应性检测系统.

研究的目的:

  • 开发一个紧的,具有成本效益和高度灵敏的LIF探测器.
  • 为了优化激发源,波长和功率,以提高检测极限.
  • 展示探测器在各种分析系统中的集成和性能,包括太空应用.

主要方法:

  • 使用可调节焦点的激光二极管和光二极管开发一个紧的LIF探测器.
  • 实现背景光校正,自适应动态范围调整和恒定激光功率控制.
  • 对激发功率对光源 (LED/LD) 和波长 (487/450 nm) 的检测极限和优化影响的实验研究.

主要成果:

  • 建造一个完全集成的模块化光LIF探测器 (40 × 22 × 38 mm3),耗资320美元.
  • 达到0.4nM的光素的检测极限.
  • 成功地集成到中国空间站 (CSS) 的核酸检测系统中,并使用PCR管和毛细血管进行测试.

结论:

  • 开发的紧型LIF探测器满足了对微型分析系统的需求.
  • 该系统表现出广泛的实用性,适应性和高灵敏度,适用于各种应用.
  • 这项技术有可能在各种环境中进行先进的分子检测,包括太空探索.