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Updated: Jun 10, 2025

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基因组广泛关联研究 (GWAS) 对于高生产率的俄罗斯霍尔斯坦牛的左移动abomasum

Kirill Plemyashov¹, Anna Krutikova¹, Angelina Belikova¹

¹Faculty of Veterinary Medicine, St. Petersburg State University of Veterinary Medicine, 196084 St. Petersburg, Russia.

Animals : an open access journal from MDPI

|October 16, 2024

概括

研究了荷尔斯坦牛对左移位腹部 (LDA) 的遗传倾向. 染色体BTA13上的一个特定区域在受影响的动物中显示出更高的患病率,这表明与这种昂贵的乳制品疾病有遗传联系.

科学领域:

动物遗传学动物遗传学
兽医医学兽医医学兽医医学
乳制品科学乳制品科学

背景情况:

左位移腹部 (LDA) 是乳牛的一个重要多因素疾病,特别是在产后期.
LDA导致牛奶产量减少和灭绝率增加,影响了群体的利能力.
之前的研究表明,对LDA易感性的遗传因素.

研究的目的:

来自列宁格勒地区的荷尔斯坦牛中识别与LDA敏感性相关的遗传标记.
探索与LDA倾向相关的基因组变异性.

主要方法:

在360头荷尔斯坦牛 (LDA受影响和健康对照) 中对同卵性性 (ROH) 的全基因组分析.
单核酸多态 (SNPs) 与LDA的识别和关联分析.
关联SNP附近的候选基因的功能注释.

主要成果:

与健康对照相比,在LDA的牛中观察到BTA13染色体上特定的ROH的患病率显著更高.
十四个候选SNP显示名义关联与LDA (p值<1 × 10−4).
确定了几个候选基因,包括ABCB11,SRP72,RGS18,SOX4,GSG1L,FBXL19和PNPLA4,这些基因可能与LDA发育有关.

结论:

该研究确定了BTA13上的基因组区域,与Holstein牛的LDA敏感性相关.
与该区域相关的候选基因可能在左移位腹部的发展中发挥作用.
这些发现有助于了解LDA的遗传基础,并可能为未来的育种策略提供信息.

关键词:

在GWAS中,GWAS就是GWAS.荷尔斯坦牛群是荷尔斯坦的牛群.在 LDA LDA 中.罗赫罗赫罗赫罗赫罗赫罗赫

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