变化的肠道微生物组合在狗与高 adrenocorticism:关键细菌基因分析
Hee-Jun Kang1, Sang-Won Kim1, Seon-Myung Kim2
1Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul 05029, Republic of Korea.
Animals : an open access journal from MDPI
|October 16, 2024
概括
狗的高 adrenocorticism 破坏肠道微生物群,减少多样性. 即使在三斯坦治疗后,这种失生症仍然存在,影响代谢健康,并建议新的治疗途径.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 微生物学 微生物学
- 内分泌学 在内分泌学.
背景情况:
- 高 adrenocorticism (HAC) 是一个常见的内分泌疾病在狗.
- HAC与各种代谢异常有关.
- 皮质醇水平升高可能会影响肠道微生物群 (GM).
研究的目的:
- 为了研究与HAC.狗的肠道微生物组合.
- 为了确定是否肠道失生症在HAC治疗后仍然存在.
- 为了确定与HAC相关的特定细菌变化.
主要方法:
- 在15只具有HAC和9只健康对照的狗中比较了转基因成分.
- 在Trilostane治疗后的5只HAC狗中分析了GM.
- 用Shannon指数进行多样性和β多样性分析进行聚类.
主要成果:
- 患有HAC的狗体现出微生物群多样性减少 (香农指数,p = 0.0148).
- 显著的转基因聚类将HAC犬与对照犬分开 (β多样性,p < 0.003).
- 在HAC犬中,蛋白质细菌,动态细菌,细菌,菌,菌,科里尼细菌,埃舍里希亚,蛋白质增加,菌减少.
结论:
- 在患有HAC的狗中存在肠道失调.
- 松症在三斯坦治疗后持续存在,可能导致正在进行的代谢问题.
- 向转基因生物异位症可能为HAC管理提供新的治疗策略.
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