肺癌发病率的性别差异:对美国两大癌症数据库的回顾性分析
Kalyan Ratnakaram1, Sai Yendamuri1, Adrienne Groman2
1Department of Thoracic Surgery, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Cancers
|October 16, 2024
概括
在高风险群体中,女性患肺癌的风险略高于男性. 需要进一步的研究,以了解非小细胞肺癌 (NSCLC) 发病率中这些性别特异性的细胞原因.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 非小细胞肺癌 (NSCLC) 的发病率在女性中相对比男性更快地上升.
- 现有的关于不同人群中NSCLC基于性别的发病率趋势的数据仍然有限.
- 高风险人群需要专门调查,以了解肺癌风险因素.
研究的目的:
- 为了回顾性研究肺癌发病率的性别差异.
- 在高风险临床队列中分析NSCLC风险.
- 确定肺癌发展中的潜在的性别差异.
主要方法:
- 分析国家肺部查试验 (NLST) 队列 (n=37,627) 的肺癌发病率,有>40包年吸烟史.
- 在前期I期肺癌患者的监测,流行病学和最终结果 (SEER) 数据库 (n=19,327) 中对第二次初级NSCLC发病率的调查.
- 应用单变量和多变量时间对事件分析来评估性别和肺癌发病率之间的关系.
主要成果:
- 在对年龄和吸烟史进行调整后,女性在NLST队列 (HR=1.11,p=0.035) 中表现出更高的初级NSCLC风险.
- 在对临床因素进行调整后,SEER队列分析显示女性患第二次原发性肺癌的风险增加 (HR=1.138,p=0.021).
- 这两个队列都表明,高风险群体中的女性与男性相比,肺癌发病率略高.
结论:
- 与高风险人群中的男性相比,女性的肺癌发病率略高.
- 这些发现凸显了进一步研究肺癌性别差异背后的生物机制的必要性.
- 了解这些差异对于NSCLC的有针对性的预防和治疗策略至关重要.
关键词:
在这里,我们可以看到NLST,NLST.在NSCLCLC中,我们可以看到NSCLCLC.塞尔·塞尔 (Seer) 是一个看得见的人.肺癌发生率 肺癌发生率性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性差异性更多相关视频
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