在乳腺癌幸存者的更年期激素治疗
Rose Culhane1, Alexandra M Zaborowski1, Arnold D K Hill1
1Department of Breast Surgery, Beaumont Hospital, P.O. Box 1297 Dublin 9, Ireland.
Cancers
|October 16, 2024
概括
在乳腺癌幸存者中使用更年期荷尔蒙疗法 (MHT) 对癌症复发呈现出不同的结果. 早期的试验表明风险增加,但较新的观察性研究发现没有显著差异,突出了进一步研究的需要.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 更年期症状显著损害了乳腺癌幸存者的生活质量.
- 有限的数据存在于与更年期荷尔蒙疗法 (MHT) 相关的瘤结果在这个人群中.
- 评估MHT复发风险对于风险/益处分析至关重要,特别是在低风险患者中.
研究的目的:
- 系统地审查当前关于MHT对乳腺癌幸存者的瘤结果影响的证据.
- 评估MHT使用与乳腺癌复发风险之间的关联.
主要方法:
- 对前性研究的系统文献综述.
- 在PubMed,EMBASE和Medline数据库中搜索英语出版物.
- 包括四项随机对照试验和四项非随机前性研究.
主要成果:
- 早期的随机试验表明,MHT的乳腺癌复发风险增加.
- 随后的观察性研究没有报告与MHT相关的复发风险增加.
- 早期试验数据和后来的观察结果之间存在差异.
结论:
- 对于MHT对乳腺癌复发的影响仍有争议,有相互矛盾的证据.
- 需要进一步的研究来精确量化MHT相关的复发风险,特别是在具有良好的分子形状的患者中.
- 有关MHT在乳腺癌幸存者的使用的知情临床讨论需要更明确的数据.
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