肺结节恶性病的血管生物标志物:动脉与静脉对比
Tong Yu1, Xiaoyan Zhao2, Joseph K Leader2
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Cancers
|October 16, 2024
概括
肺结节恶性瘤可以通过分析周围动脉来预测. 靠近结节的动脉是区分恶性和良性肺结节的关键指标.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 肺部医学 肺部医学
背景情况:
- 肺结节是低剂量计算机断层扫描 (LDCT) 肺癌查中的常见发现.
- 区分恶性和良性肺结节对于患者管理至关重要.
- 周围血管系统在结节特征中的作用仍然是积极研究的领域.
研究的目的:
- 为了研究肺动脉和围绕结节的静脉与其恶性瘤之间的联系.
- 确定宏血管学特征是否可以提高肺结节分类的准确性.
主要方法:
- 利用了来自LDCT肺癌查计划的146名受试者的数据集.
- 采用人工智能算法来自动细分和量化结节和周围的宏血管 (动脉和静脉).
- 量化血管分支数量,体积和扭曲度在不同距离结节表面的不同距离.
- 执行后勤回归 (LR) 和接收器运行特征曲线下面面积 (ROC-AUC) 分析.
主要成果:
- 采用宏血管特征的LR模型,所有结节的AUC为0.78,8-20毫米结节的AUC为0.67.
- 结合宏血管学,人口学和CT衍生的结节特征的模型达到0.91 (所有结节) 和0.82 (结节8-20毫米) 的AUC.
- 距离结节表面5.0毫米以内的动脉是最重要的宏血管学预测指标,并保留了额外的特征的重要性.
结论:
- 靠近肺结节的动脉 (在5.0毫米以内) 显示出作为恶性瘤生物标志物的潜力.
- 宏血管分析,特别是邻近动脉的分析,可以提高肺结节的诊断性能.
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