结肠直肠癌的预后研究:屏幕检测和症状诊断患者之间的差异
Sergio A Novotny1, Vidina A Rodrigo Amador1, Jordi Seguí Orejuela1
1Department of General and Digestive Surgery, Elda General University Hospital, Carretera de Sax s/n, 03660 Elda and San Juan de Alicane, Spain.
Cancers
|October 16, 2024
概括
结肠直肠癌 (CRC) 查导致更早的诊断和改善的生存率. 这项研究强调了西班牙CRC查计划的好处,以改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 大肠直肠癌 (CRC) 是西班牙的主要死亡原因.
- 包括便隐性血液检测和结肠镜检查在内的CRC查计划是有效的,但吸收率低.
- 了解查与基于症状的诊断对生存的影响至关重要.
研究的目的:
- 在查和症状诊断患者之间比较CRC诊断阶段,死亡率 (全因和疾病特异性).
- 确定CRC患者的死亡风险因素.
- 评估查对生存和早期检测的有效性.
主要方法:
- 在西班牙埃尔达诊断出315名CRC患者的回顾性队列研究 (2014-2018).
- 随访到2023年或死亡,使用卡普兰-梅尔曲线分析所有原因的死亡率.
- 研究的CRC特异性和其他原因死亡率.
主要成果:
- 查组显示早期阶段诊断 (0-I) 和远端瘤.
- 症状组有晚期诊断 (II-IV),近位瘤和更多的慢性疾病.
- 诊断时的第四阶段和先前的癌症是死亡风险因素;基于症状的诊断与较高的CRC和全因死亡率相关.
结论:
- 结肠直肠癌查有助于更早的诊断,并提高患者的生存率.
- 结果支持公共卫生倡议,促进可访问和有效的CRC查计划.
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