与瘤相关的巨细胞作为瘤微环境中的主要免疫抑制细胞
Anghesom Ghebremedhin1, Dipti Athavale1, Yanting Zhang1,2
1Coriell Institute for Medical Research, 403 Haddon Ave., Camden, NJ 08103, USA.
Cancers
|October 16, 2024
概括
本综述探讨了免疫抑制的M2型瘤相关巨细胞 (TAMs) 以及它们在癌症进展中的作用. 针对这些TAM为各种癌症提供了有前途的治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 瘤微环境 (TME) 中的髓状细胞是具有多种功能的免疫细胞.
- 类似M2的瘤相关巨细胞 (TAMs) 具有免疫抑制作用,促进瘤生长.
研究的目的:
- 审查M2类TAMs的复杂生物学.
- 探索巨细胞极化和可塑性的信号机制.
- 讨论针对癌症TAM的治疗策略.
主要方法:
- 关于TAMs的最近研究的文献综述.
- 分析参与巨细胞两极分化的信号通路.
- 对针对TAM的治疗方法的评估.
主要成果:
- 类似M2的TAMs有助于瘤细胞的入侵,转移和 stromal 重塑.
- 巨细胞两极分化是由复杂的信号机制调节的.
- 向TAM显示在癌症治疗中具有治疗潜力.
结论:
- 了解不同的免疫抑制TAM子集对于癌症治疗至关重要.
- 消耗或调制TAM是一种有前途的治疗途径.
- 对TAM生物学的进一步研究可能会导致新的癌症治疗方法.
相关概念视频
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Tumor Immunotherapy
488
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
488
Mesenchymal Stem Cells
4.6K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.6K
T Cell Types and Functions
959
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
959


