在三级系统中Neohesperidin与Hydroxypropyl-β-cyclodextrin和Meglumine的分子相互作用和溶解效率
Na Xia1,2,3, Yanquan Liu1,2,3, Dan Gao4
1College of Life and Geographic Sciences, Kashi University, Kashi 844000, China.
Foods (Basel, Switzerland)
|October 16, 2024
概括
这项研究开发了一种三元纳入复合物,以显著提高Neohesperidin (NH) 溶解度. 这种新的系统,使用环氧和大,增强了NH的水溶性超过36倍.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 生物化学 生物化学
背景情况:
- 溶解水溶性较差的天然化合物是药物开发中的一个关键挑战.
- 新素 (NH) 是一种具有有限水溶性的生物活性黄,阻碍了其治疗应用.
研究的目的:
- 设计和优化一个三元纳入复杂系统,以提高Neohesperidin (NH) 的可溶性.
- 研究优化系统的复杂化机制和结构特征.
主要方法:
- 准备和优化涉及NH,2-基-β-基 (HP-β-CD) 和大光氨酸 (MEG) 的三元循环氨酸复合物 (t-CD).
- 使用扫描电子显微镜 (SEM),粉末X射线衍射 (PXRD),差分扫描热量计 (DSC),里叶变换红外光谱 (FTIR),核磁共振 (NMR) 和分子对接 (MD) 的表征.
主要成果:
- 优化的t-CDs显示NH溶解度从0.16 mg/mL显著增加到5.81 mg/mL在37°C.
- 特性研究表明NH和MEG之间形成键,随后被纳入HP-β-CD疏水腔.
结论:
- 三元包容系统有效地提高了Neohesperidin (NH) 的水溶性.
- NH,MEG和HP-β-CD之间的协同相互作用对于提高溶解度至关重要,为提高NH的生物可用性和治疗疗效铺平了道路.
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