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松花粉多糖和硫酸多糖对小鼠性结肠炎的影响通过调节Th17/Treg

Zhanjiang Wang¹, Zhenxiang Li¹, Hanyue Wang¹

¹Key Laboratory of Food Nutrition and Safety of SDNU, College of Life Science, Shandong Normal University, Jinan 250358, China.

Foods (Basel, Switzerland)

|October 16, 2024

概括

松花粉多糖 (PPM60-III) 和硫酸多糖 (SPPM60-III) 通过重新平衡肠道免疫力和新陈代谢来缓解性结肠炎 (UC). 在小鼠模型中,SPPM60-III显示出卓越的抗结肠炎作用.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
代谢学代谢学代谢学

背景情况:

性结肠炎 (UC) 是一种具有复杂病原性的慢性炎症性肠病.
维持T辅助细胞17 (Th17) 和调节性T (Treg) 细胞之间的平衡对于免疫平衡至关重要.
肠道微生物群失调和变化的代谢物概况与UC发育和进展有关.

研究的目的:

研究松花粉多糖 (PPM60-III) 和硫酸多糖 (SPPM60-III) 对小鼠DSS诱导的UC的治疗作用.
评估它们对Th17/Treg细胞平衡,炎症性细胞因子产生,肠道微生物群组成和代谢物分布的影响.

主要方法:

在小鼠中诱导UC使用3%的硫酸 (DSS) 在饮用水中.
将PPM60-III和SPPM60-III给UC小鼠使用.
评估生理参数,包括Treg细胞计数和炎症性细胞因子.
使用16S rRNA测序分析肠道微生物组合的分析.
使用代谢学分析代谢物分布的概况.

主要成果:

两种PPM60-III和SPPM60-III都缓解了UC症状,由减少的肝Treg细胞,重新平衡的Th17/Treg比率和调节的炎症细胞因子证明.
微生物群分析显示,Beijerinck和Bifidobacterium的含量下降,Akkermansia,Escherichia coli和Fidobacteria的含量增加.
代谢学表明,修复纯素和糖脂代谢,以及上调尼古丁酸盐,尼古丁胺胺和咖啡因代谢,有助于抑制炎症.

结论:

松花粉多糖,特别是SPPM60-III,在DSS诱导的UC小鼠模型中表现出显著的抗结肠炎活性.
这些化合物通过调节肠道细菌的组成和恢复代谢途径来发挥治疗作用.
与PPM60-III相比,SPPM60-III显示出更强大的抗结肠炎疗效.

关键词:

在Th17细胞中.在Treg细胞中.肠道菌群是指肠道上的植物.松花粉的多糖是松花粉的多糖.性结肠炎是一种

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