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在多发性硬化病变中对HLA-DR-免疫阳性细胞的形态学研究及其对病变发生的影响

Murad Alturkustani1,2, Lee-Cyn Ang2,3

  • 1Department of Pathology, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Diagnostics (Basel, Switzerland)
|October 16, 2024
PubMed
概括

在多发性硬化症 (MS) 病变中,巨细胞主导活跃斑块,而分支的微质细胞在慢性活跃病变中普遍存在,这表明它们在疾病进展和稳定性中起着不同的作用.

关键词:
具有HLA-DR免疫阳性的细胞.长期活跃斑块 长期活跃斑块巨细胞是什么?巨细胞是什么?多发性硬化症 多发性硬化症有分支的微质细胞

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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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