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在ALS中,语音运动障碍与原发性运动皮层以外的多区域皮层稀释有关
Ana Luiza Zaninotto1, Meena M Makary2,3, Hannah P Rowe1,4
1Department of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA, United States.
Frontiers in neurology
|October 16, 2024
概括
肌缩侧面硬化症 (ALS) 导致大脑变化,特别是皮质稀薄,与语言问题有关. 这项研究发现,ALS患者的发言能力受损,但发言能力保持不变的患者的运动和身区域变薄.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 皮质稀薄是已知的肌缩侧面硬化症 (ALS) 的指标.
- 在ALS中皮层稀疏和语音恶化之间的关系还不清楚.
- 这项研究调查了ALS患者关于语言障碍模式的大脑解剖学.
研究的目的:
- 为了将ALS患者的皮层厚度模式与健康对照 (HCs) 的言语变化和没有言语变化进行比较.
- 确定受皮层稀释影响的特定大脑区域,与ALS语音衰退相关.
- 探索不同类型的肌痛性关节障碍与ALS皮质变化之间的联系.
主要方法:
- 磁共振成像 (MRI) 用于评估40名ALS患者和22名HC患者的皮质厚度.
- ALS患者被分为保留语音 (ps-ALS) 和语音恶化 (ds-ALS) 组.
- 进行了全脑和感兴趣区域 (ROI) 分析,重点关注16个预定义的大脑区域.
主要成果:
- 与HC相比,d-ALS组在运动和体感皮层以及下叶中显示出显著的皮质稀释.
- 与HC相比,ps-ALS组没有表现出显著的皮质稀释.
- 在运动和前运动区域观察到皮质稀薄,在d-ALS组中观察到前带状皮质.
结论:
- ALS涉及广泛的新皮层变化,影响语言的产生.
- 在特定的大脑区域的皮层厚度变化与ALS的言语恶化相关.
- 需要进一步的研究,包括纵向研究,以澄清ALS中MRI-语音-气囊管功能障碍的联系.
关键词:
这就是为什么MRI是MRI.肌缩侧面硬化症 (ALS) 是一种疾病.大脑缩 大脑缩脱节性关节障碍症 脱节性关节障碍症是一种疾病.神经退行症的神经退行症语言障碍 语言障碍 语言障碍语音运动控制 语音运动控制更多相关视频
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