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相关概念视频

Teeth01:15

Teeth

339
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
339
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.8K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

3.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.8K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

4.4K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.4K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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相关实验视频

Updated: Jun 10, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
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Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

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KMT2D调节了牙面膜的发育.

Jung-Mi Lee1, Hunmin Jung1, Qinghuang Tang1

  • 1Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, NY 14214, U.S.A.

bioRxiv : the preprint server for biology
|October 16, 2024
PubMed
概括
此摘要是机器生成的。

KMT2D基因对于牙质形成至关重要. 在小鼠中缺少它会导致缺陷的牙,类似于人类的卡布基综合征,通过在乳腺细胞分化过程中破坏关键基因表达.

关键词:
细胞分化的细胞分化.面是用乳进行的.皮质上皮质上皮质上皮质上基因表达 基因表达 基因表达形态发生 形态发生 形态发生牙的发育 牙的发育

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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相关实验视频

Last Updated: Jun 10, 2025

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants
08:12

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
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Accessing the Cytotoxicity and Cell Response to Biomaterials
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科学领域:

  • 发育生物学 发展生物学
  • 遗传学 是一个遗传学.
  • 口腔生物学 口腔生物学

背景情况:

  • 杏仁生成对于牙质形成和保护至关重要.
  • 缺陷的乳腺发育会导致乳腺发育不完美,包括乳的低成形.
  • KMT2D基因突变与卡布基综合征和牙异常有关,但其在乳腺发育中的作用尚不清楚.

研究的目的:

  • 调查KMT2D在乳腺生成中的特定作用.
  • 用有针对性的KMT2D删除对小鼠的牙缺陷进行表征.

主要方法:

  • 生成了一个有条件淘汰赛小鼠模型 (Krt14-Cre;Kmt2d) 具有外皮特异性的Kmt2d删除.
  • 使用微CT,SEM,组织学和分子技术分析了质缺陷.
  • 执行RNA-seq和CUT&RUN-seq以识别KMT2D调节的基因.

主要成果:

  • Kmt2d-cKO小鼠表现出100%的透性非完美的乳腺发育,具有低可塑性和低矿物质化的乳液.
  • 新生儿Kmt2d-cKO小鼠表现出微妙的尖端变化和延迟的乳腺细胞分化.
  • KMT2D直接向Satb1和Sp6等基因,这些基因对于乳腺细胞分化至关重要.

结论:

  • KMT2D对于正常的骨髓发育至关重要,它调节了对骨髓细胞分化至关重要的基因表达.
  • 这项研究提供了关于膜发育和卡布基综合征相关牙缺陷的分子机制的见解.