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Updated: Jun 10, 2025

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
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DNA聚合酶甲基介导的DNA修复是DNMT3A缺乏白血病细胞的功能依赖和治疗脆弱性

Bac Viet Le, Umeshkumar Vekariya, Monika M Toma

    bioRxiv : the preprint server for biology
    |October 16, 2024
    PubMed
    概括

    基因聚合酶甲基 (Polθ) 对于具有DNMT3A突变 (DNMT3Amut) 的骨髓性恶性瘤至关重要. 抑制Polθ增强了标准疗法,为这些抗性白血病类型提供了新的治疗策略.

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