在巴拿马检测到登革热病毒血清型4在23年没有循环后的巴拿马
María Chen-Germán1, Dimelza Araúz1, Celestino Aguilar2,3
1Modular Specialized Laboratory, Department of Research in Virology and Biotechnology, Gorgas Memorial Institute for Health Studies, Panama City, Panama.
Frontiers in cellular and infection microbiology
|October 16, 2024
概括
登革热病毒4型 (DENV-4) 在巴拿马出现了23年的缺席后,在2023年底与其他血清型一起检测到. 这次复苏恰逢一个不寻常的干旱季登革热暴增,突出显示了持续监测的必要性.
科学领域:
- * arboviruses 的病毒学和流行病学.
- * 公共卫生和传染病监测.
- * 登革热病毒的分子流行病学.
背景情况:
- *自1993年以来,巴拿马经历了流行性登革热病毒 (DENV) 传播,所有四种血清型都在流传.
- *自2000年以来,巴拿马没有确认本土DENV-4病例,尽管有区域传播.
- *登革热的爆发通常与热带地区的雨季有关.
研究的目的:
- * 报告最近在巴拿马发现和描述4型登革热病毒 (DENV-4) 的情况.
- * 调查检测到的DENV-4菌株的遗传谱系和潜在来源.
- * 评估DENV-4复发的流行病学影响,包括季节性模式.
主要方法:
- *使用分子方法检测患者样本中的DENV RNA.
- * DENV-4分离物的全基因组测序.
- *植物遗传学分析以确定基因型和识别相关菌株.
- * DENV检测与登革热病例数据和季节性的相关性.
主要成果:
- *DENV-4在2023年最后四个月在巴拿马检测到,与其他DENV血清型共传播.
- *登革热病例的峰值发生在干旱季节,与典型的雨季疫情形成鲜明对比.
- * 完整的DENV-4基因组揭示了IIb基因型,与2023年尼加拉瓜和萨尔瓦多的菌株有很高的相似性.
- *检测到的DENV-4基因型与23年前在巴拿马发现的基因型相同.
结论:
- * DENV-4基因型IIb在巴拿马的重新出现意味着一个重要的病毒循环事件.
- * 不寻常的干旱季节登革热峰值突显了该疾病不断变化的流行病学.
- *持续的血清型和基因型监测对于早期检测新的DENV变种和有效的公共卫生反应至关重要.
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