在新生儿重症监护病房的婴儿中治疗狂妄症的 gabapentin
Eugenie Chang1, Avery Parman2, Peter N Johnson2
1Department of Pharmacy (EC), Bethany Children's Health Center, Oklahoma City, OK.
概括
在大多数情况下, gabapentin 有效地控制了新生儿重症监护室 (NICU) 的妄想,减少了疼痛和戒断症状. 这项研究强调了 gabapentin 的重要性.
科学领域:
- 新生儿药理学和重症监护.
- 儿科神经学和重症监护医学.
- 在脆弱人群中妄症的管理.
背景情况:
- 新生儿重症监护室 (NICU) 妄症是一个重大的临床挑战.
- 一个结构化的协议涉及 gabapentin,黑激素和抗精神病药物被开发为NICU Delirium管理.
- 在这个人群中了解 gabapentin 的特定效用和最佳剂量至关重要.
研究的目的:
- 描述 gabapentin 的临床实用性和精确的剂量策略,用于在NICU 患者中管理妄症.
- 为了评估 gabapentin 作为一线 (第一步) 或二线 (第二步) 药物的作用,在已建立的NICU Delirium 协议中.
- 评估是否需要升级到第三线治疗,如抗精神病药物.
主要方法:
- 在2021年1月至2022年12月期间,29名接受 gabapentin 治疗痴呆症的NICU患者的回顾性分析.
- 收集的数据包括患者人口统计, gabapentin 剂量方案和同时使用镇静剂/止痛药.
- 评估疼痛 (EDIN),妄 (CAPD) 和戒断 (WAT-1) 评分的变化,以及药物使用,加巴丁前后启动.
主要成果:
- 在75.9%的患者中, gabapentin被用作第一步治疗;没有患者需要第三步抗精神病治疗.
- 中位初始加巴丁剂量为14.4mg/kg/天,其中41.4%需要剂量升级.
- 观察到疼痛 (EDIN) 和戒断 (WAT-1) 评分显著降低,而妄想 (CAPD) 评分和其他药物剂量保持不变.
结论:
- gabapentin 经常被用作NICU狂妄症的初始疗法,通常处于大约14毫克/公斤/天的中位数剂量.
- 加巴丁的使用与新生儿疼痛和戒断症状的显著减少有关.
- gabapentin 证明在管理NICU狂妄症方面具有实用性,可能减少对更强大的干预措施的需求.
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