在瑞典基于人口的双胞胎样本中,父母报告的言语和/或语言困难的患病率和遗传性
Rebecka Keijser1,2, Jakob Åsberg Johnels3,4, Marika Habbe1,2
1The Center of Neurodevelopmental Disorders (KIND) Centre for Psychiatry Research Department of Women's and Children's Health Karolinska Institutet and Child and Adolescent Psychiatry Stockholm Health Care Services Stockholm County Council Stockholm Sweden.
JCPP advances
|October 16, 2024
概括
语音和/或语言困难 (SaLD) 很常见,影响7.85%的儿童. 遗传因素对SaLD有很大的影响,在这个基于人群的双胞胎研究中估计占75%的遗传性.
科学领域:
- 遗传学 是一个遗传学.
- 发展心理学 发展心理学
- 公共卫生 公共卫生
背景情况:
- 对言语和/或语言困难 (SaLD) 的遗传和环境影响的研究是有限的,遗传概率估计各不相同.
- 了解这些影响对于开发有效的干预和支持策略至关重要.
研究的目的:
- 在瑞典人口中估计父母报告的SaLD的流行率.
- 通过双胞胎研究设计,确定遗传和环境因素对SaLD的相对贡献.
主要方法:
- 利用了来自瑞典儿童和青少年双胞胎研究的数据,包括16774对双胞胎.
- 采用经典的双胞胎设计,并通过自闭症-提克,注意力缺陷多动症障碍和其他并发症库存提供家长报告.
- 分类了父母报告的SaLD的个体,以分析遗传和环境影响.
主要成果:
- 沙尔德的患病率为7.85%,男性患病率为2:1
- 对SaLD的遗传概率估计相当大,为75%,共享环境贡献22%.
- 除了自闭症和智力障碍的个体,遗传能力略有降低到70%,但有重叠的置信区间.
结论:
- 沙尔德是一种普遍存在的疾病,具有重要的遗传成分.
- 这些发现强调了 SaLD.在病因学中的遗传因素的重要性.
- 未来的研究应该调查SALD和相关发育障碍背后的遗传结构.
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