针对父母患有严重精神疾病的孩子的家庭预防性干预:一项随机临床试验
Anne Dorothee Müller1,2, Ida Christine Tholstrup Gjøde1,2, Nikolaj Thams3
1Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark.
JCPP advances
|October 16, 2024
概括
与通常治疗相比,VIA Family干预措施没有显著改善父母患有严重精神疾病的孩子的整体功能. 需要进一步的研究来探索潜在的长期预防作用.
科学领域:
- 儿童和青少年精神病学 儿童和青少年精神病学
- 家庭干预 家庭干预
- 心理健康研究 心理健康研究
背景情况:
- 父母患有严重精神疾病的儿童面临患精神疾病的风险较高.
- 一个以家庭为基础的预防性干预,VIA Family,是为了支持这些弱势儿童而开发的.
- 了解这种干预措施的有效性对于早期干预策略至关重要.
研究的目的:
- 为了比较VIA家庭干预与通常治疗 (TAU) 的有效性,以改善父母有严重精神疾病病史的儿童的整体功能.
- 评估VIA Family对儿童情绪和行为问题以及上学的影响.
主要方法:
- 在丹麦进行了一项务实,评级者盲目的,双臂并行组优越性试验.
- 95个家庭有113个孩子 (6-12岁),其中一个父母患有精神分裂症谱系障碍,双相情感障碍或复发性抑郁症,被随机分配到VIA家庭或TAU.
- 在基线和18个月后,使用儿童全球评估量表 (CGAS) 评估了儿童的全球功能.
主要成果:
- 在干预后,VIA家族和TAU组之间没有观察到全球功能平均变化的显著差异 (CGAS:-1.20,95%CI = -6.61;4.21,p = 0.66).
- 二次结果,包括情绪和行为问题和缺学,也显示了两组之间的非显著差异.
结论:
- 在这项研究中,VIA Family干预没有显示出与通常治疗相比更好的效果.
- 零结果可能归因于短时间的随访期和样本异质性.
- 维亚家庭干预措施的长期预防效应需要进一步研究.
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