在肝细胞癌中组织学证明的转移的模式和临床病理学特征
Muhammad Zamil1, Hina Maqbool1, Sajid Mushtaq1
1Pathology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.
Cureus
|October 16, 2024
概括
肝细胞癌 (HCC) 经常转移到不寻常的部位,最常见的是骨. 这项研究详细介绍了转移模式和诊断特征,有助于识别未知的原发性瘤.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 肝细胞癌 (HCC) 是一种流行且具有攻击性的肝癌.
- HCC经常转移,有时转移到意想不到的位置,这给诊断带来了挑战.
- 了解转移模式对于患者的管理和诊断至关重要.
研究的目的:
- 调查HCC.异常的转移部位和模式.
- 分析转移性HCC的临床病理特征.
- 为了确定研究人口中HCC的常见原因.
主要方法:
- 从2016年到2022年对257例转移性HCC病例进行了回顾性分析.
- 对转移部位,组织学模式和诊断方法进行系统的数据提取.
- 使用免疫组织化学染料,包括HepPar1和glypican-3,用于诊断.
主要成果:
- 骨头是最常见的转移部位 (52.5%),脊柱是最常见的骨部位 (24.7%).
- 主要的组织学模式是纯状 (74.7%).
- 免疫组织化学,特别是HepPar1和glypican-3,被证明是诊断的关键.
结论:
- 转移性HCC表现出多样化的模式,并且可以在不寻常的地点发生.
- 组织学和免疫组织化学特征对于诊断转移性HCC至关重要,特别是对于未知的原发性瘤.
- 这项研究提供了对过去二十年中转移性HCC特征的全面见解.
相关概念视频
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
Liver Histology
619
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
619


