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MMP-9-C1562T多态性和对孕前的敏感性之间的关联:系统性审查和元分析

Ruihong Lan¹, Yang Yang¹, Jie Song¹

¹Department of Obstetrics, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, China.

Ginekologia polska

|October 16, 2024

概括

MMP-9-C1562T多态,特别是CT基因型,与孕前 (PE) 的风险增加有关. 这种遗传关联突显了PE易受性的潜在因素,特别是在高加索人群中.

科学领域:

遗传学遗传学是一个
产科产科产科产科产科
分子生物学分子生物学

背景情况:

孕前 (PE) 是一种具有复杂病因的严重妊娠并发症.
遗传因素越来越多地被认为有助于PE易感性.
矩阵金属蛋白酶-9 (MMP-9) 在血管改造和植入中发挥作用,使其遗传变异成为PE的潜在风险因素.

研究的目的:

调查MMP-9-C1562T基因多态化与患孕前的风险之间的关联.
通过元分析综合现有证据,以确定这种多形态对PE易感性的整体影响.

主要方法:

进行了系统性审查和元分析,搜索了四个英语数据库,查找到2024年4月发布的相关研究.
包括调查MMP-9-C1562T多态和孕前的研究.
聚合赔率比率 (OR) 和置信区间 (CI) 使用 Stata 15.0 计算来评估相关性.

主要成果:

包含元分析的十项研究表明,在MMP-9-C1562T位点的CT基因型与TT基因型相比,显著增加了PE的风险 (OR = 2.32,95% CI: 1.27-4.24,P = 0.006).
对于其他遗传模型 (例如,C与T,CC与TT,CC+CT与TT,CC与CT+TT) 没有发现显著的关联.
亚组分析表明,在异合体模型 (CT vs TT) 中,特别是在中国人群中,具有统计学意义的风险增加 (OR = 2.38,95% CI: 1.15-4.91,P = 0.019).

结论:

MMP-9-C1562T多态性与孕前的易感性有关.
在这个位置的CT基因型会增加患PE的风险.
进一步的研究可能会探索这种与孕前的遗传关联中的特定机制和种族变异.

关键词:

在MMP-9中,它是MMP-9的.这是一个元分析.多形态主义的多态主义.易感性易感性易感性

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