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在怀孕期间暴露于比克特格拉维尔后的出生结果
Rosemary Olivero1, Paige L Williams2,3, George Sawyer2
1Helen DeVos Children's Hospital of Corewell Health, Michigan State University, Grand Rapids, MI.
AIDS (London, England)
|October 16, 2024
概括
怀孕时使用比克特格拉维尔治疗艾滋病毒感染者 (PWH) 在美国队列中没有显著的安全问题,大多数婴儿出生时,没有报告新生儿死亡或艾滋病毒传播. 建议进一步监测bictegravir的怀孕结果.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 比克特格拉维尔 (Bictegravir) 是联合配方抗逆转录病毒疗法的组成部分,越来越多地用于艾滋病毒感染 (PWH) 的孕妇.
- 在怀孕期间暴露于比克特格拉维尔后,关于怀孕和分娩结果的数据有限.
研究的目的:
- 为了评估在怀孕期间暴露于比克特格拉维尔的婴儿的出生结果.
- 评估比克特格拉维尔在孕妇PWH中的安全性.
主要方法:
- 在怀孕期间暴露于比克特格拉维尔≥7天的PWH产生的婴儿的描述性分析.
- 通过儿科艾滋病毒/艾滋病队列研究 (PHACS) 收集的数据.
- 结果包括妊娠年龄,早产,出生体重和长度Z-分数,对于妊娠年龄来说很小,先天性异常,新生儿死亡和婴儿艾滋病毒状况.
主要成果:
- 177名婴儿在怀孕期间暴露于比克特格拉维尔;55%的婴儿从怀孕开始暴露.
- 中位妊娠年龄在出生时是38.1周;早产发生在15.8%和SGA在9.3%.
- 没有新生儿死亡或围产期艾滋病毒传播;5.6%的婴儿在第一季度接触了比克特格拉维尔,有重大先天性异常,没有特定的模式.
结论:
- 预先的数据表明,对胎儿的比克特格拉维尔暴露没有显著的安全问题.
- 需要继续进行监测和比较研究,以进一步了解在怀孕期间使用比克特格拉维尔的情况.
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