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制备和描述封装水溶性有效物质的通用液态型体

Li Xu¹, Zhaohe Huang¹, Xiaojing Pei¹

¹Institute of Regulatory Science, School of Light Industry Science and Engineering, Beijing Technology and Business University, Beijing 100048, P. R. China.

Current pharmaceutical biotechnology

|October 16, 2024

概括

研究人员开发了通用液体体,实现了超过85%的水溶性物质封装效率和37.5%的药物载荷能力. 这些益波体为化品和制药应用提供了增强的稳定性.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

脂质体因其生物相容性和封装能力而广泛应用于化品和药品中.
脂质体的挑战包括稳定性差,复杂的制备和有限的封装效率 (EE%) 和药物载荷能力 (DLC%).

研究的目的:

开发通用液态质体,以改善脂质体的制备.
为了优化proliposome配方以提高稳定性和封装.

主要方法:

使用旋转蒸发方法制备了通用液态益波体.
配方通过改变pH值,糖醇含量,乙醇含量和制备工艺来优化配方.

主要成果:

对于水溶性物质,封装效率 (EE%) 超过85%,最大药物载荷能力 (DLC%) 为37.5%.
在各种条件下,最佳的多细胞组合表现出超过60天的稳定性.
使用Turbiscan稳定性分析仪证实了在化品配方中的普利波和尼古丁胺脂质体的优异稳定性.

结论:

开发的全方位液态体使体能够快速形成,封装各种水溶性物质.
这项技术提供了一种可访问和多功能方法,以提高水溶性原材料在配方中的稳定性和适用性.

关键词:

液体的前立体体是液体的前立体体.封装效率. 封装效率. 封装效率. 封装效率. 封装效率.稳定的稳定性稳定的稳定性在水中溶解的功能性物质

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