AKT2介导的溶酶体功能障碍促进了视网膜色素表皮 (RPE) 细胞中的分泌性自

Sayan Ghosh1, Stacey Hose1, Debasish Sinha1

  • 1Department of Ophthalmology, The Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Autophagy
|October 16, 2024
PubMed
概括

视网膜细胞中AKT2的增加会触发分泌性自,这种途径有助于与年龄相关的黄斑变性 (AMD) 和德鲁森形成. 通过抑制这一过程,SIRT5可以提供保护.

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