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Updated: Jun 10, 2025

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肝炎三角抗原保留了组装域作为唯一的固态实体

Yang Yang1, Marie-Laure Fogeron1, Alexander A Malär2

  • 1Molecular Microbiology and Structural Biochemistry (MMSB) UMR 5086 CNRS/Université de Lyon, Labex Ecofect, 7 Passage du Vercors, 69367 Lyon, France.

Journal of the American Chemical Society
|October 16, 2024
PubMed
概括

研究人员使用先进的NMR研究了型肝炎病毒 (HDV) 的S-HDAg蛋白. N端组件域是刚性的,而其余的蛋白质是动态的,提供了对病毒RNP复合物的洞察力.

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Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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