肝脏成像报告和数据系统研究中的偏差风险使用QUADAS-2
Haresh Naringrekar1, Andreu F Costa2, Eric Lam3
1Department of Radiology, Thomas Jefferson University Hospitals, Philadelphia, PA, USA.
概括
大多数关于肝脏成像报告和数据系统 (LI-RADS) 的研究表明,存在高风险的偏见和适用性问题. 改善患者选择和研究流程对于可靠的LI-RADS研究至关重要.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 诊断的准确性 诊断的准确性
背景情况:
- 肝脏成像报告和数据系统 (LI-RADS) 对于高危患者的肝细胞癌 (HCC) 管理至关重要.
- 评估LI-RADS研究的质量对于确保诊断准确性研究的可靠性至关重要.
研究的目的:
- 通过使用定制的诊断准确性研究-2 (QUADAS-2) 质量评估工具,评估已发表的LI-RADS研究的偏差风险和适用性.
- 确定LI-RADS研究中最为导致偏见和适用性问题的特定领域.
主要方法:
- 基于共识的方法被用来为LI-RADS出版物量身定制QUADAS-2工具.
- 评估了2017-2022年的37份LI-RADS相关出版物,评估了CT,MRI或对比增强超声波对HCC的评估.
- 评估是由两位作者独立进行的,分歧由第三位专家审查员解决.
主要成果:
- 在37个LI-RADS研究中,有31个 (84%) 被认为存在高偏差风险.
- 在37项 (24%) 研究中,有9项研究对适用性提出了担忧.
- 在患者选择 (21/37) 和流动/定时 (24/37) 领域观察到偏差风险最高.
结论:
- 很大一部分LI-RADS研究显示出严重的偏见风险和适用性问题.
- 解决患者选择,排除和验证偏差方面的局限性对于提高LI-RADS研究的有效性至关重要.
- 需要严格的质量评估,以了解当前LI-RADS研究的局限性,并指导未来的研究改进.
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