设备测量静止行为和心血管和静态循环系统疾病发病率
Matthew N Ahmadi1,2, Pieter Coenen3,4, Leon Straker5
1Mackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Camperdown, NSW, Australia.
International journal of epidemiology
|October 16, 2024
概括
过度坐着会增加心血管疾病 (CVD) 和静态循环疾病的风险. 长时间站立不会降低心血管疾病的风险,可能会增加静态循环系统疾病的风险,而坐着会导致负面的健康结果.
科学领域:
- 心血管健康和生活方式医学.
- 慢性疾病的流行病学.
- 职业和环境健康.
背景情况:
- 以前的研究表明,站立有利于代谢标记物,而坐着是有害的.
- 有限的研究探讨了久坐不动行为和心血管/静止循环系统疾病之间的剂量反应关系.
研究的目的:
- 调查每日坐,站和总静止时间与心血管疾病 (CVD) 和静止循环系统疾病的发生率之间的关联.
主要方法:
- 利用了来自83013名英国生物库参与者的加速度计数据 (平均年龄61.3岁,55.6%是女性).
- 评估了每天坐着和站着的时间,定义了主要的心血管疾病和静态循环系统疾病.
- 使用Cox比例危险回归与限制立方线和Fine-Gray竞争风险模型来估计剂量反应危险比率.
主要成果:
- 在6.9年的时间里,发生了6829次心血管疾病和2042次静态循环疾病事件.
- 高静止时间 (>12小时/天) 增加了静止性循环系统疾病风险 (HR 0.22/小时) 和心血管疾病风险 (HR 0.13/小时).
- 每增加一个小时的坐着时间 (>每天10小时) 会增加静态循环系统疾病的风险 (HR 0.26) 和心血管疾病的风险 (HR 0.15);站着时间与心血管疾病没有关联,但会增加静态循环系统疾病的风险.
结论:
- 站立时间与主要心血管疾病 (CVD) 风险无关,但与静态循环系统疾病风险增加有关.
- 每天超过10小时的坐着时间与静态循环系统疾病和主要心血管疾病的风险更高有关.
- 减少坐着的时间至关重要,因为它主要驱动着总体久坐行为对健康的不利影响.
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