相关实验视频
Updated: Jun 10, 2025

00:07
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.2K
减少ING3的核免疫表达是唇癌发生的频繁事件
Joyce Magalhães de Barros1, Hannah Gil de Farias Morais2, Carla Samily de Oliveira Costa1
1Department of Oral Pathology, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, Lagoa Nova, Natal, 1787, CEP 59056-000, RN, Brazil.
Head and neck pathology
|October 16, 2024
概括
与行为性炎相比,ING3核表达在状细胞癌中显著下降,这表明在唇癌进展期间瘤抑制功能受损.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 皮肤病学 皮肤病学
背景情况:
- 行动性炎是一种下唇的先发性病变.
- 状细胞癌 (SCC) 是唇部常见的一种恶性瘤.
- ING3是一种参与细胞循环调节的瘤抑制基因.
研究的目的:
- 为了评估ING3在行为性炎和下唇SCC中的免疫组织化学表达.
- 为了比较ING3蛋白表达模式在行为性炎和SCC之间.
- 分析ING3表达与临床病理学变量之间的关联.
主要方法:
- 免疫组织化学被用来检测ING3表达在45个行动性乳头炎和48个下唇SCC标本.
- 在不同的细胞子部位 (细胞核,细胞质) 中分析了ING3蛋白表达.
- 统计分析比较了不同组之间的ING3表达和临床病理变量.
主要成果:
- 在SCC中,ING3核细胞体表达明显低于行动性炎.
- 细胞质ING3表达在SCC中明显高于行动性炎.
- 在行为性炎中,ING3表达与组织病理学分级有显著差异,但在SCC中没有.
结论:
- 核ING3表达的显著下降发生在恶性进展过程中,从行为性炎到SCC.
- 这表明ING3的瘤抑制功能受损在下唇SCC的发展.
- ING3可能成为唇癌进展的潜在生物标志物.
相关概念视频
Non-LTR Retrotransposons
11.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
11.4K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K

