侵袭性真菌鼻炎:越南的第一个组织病理学研究
Giang Huong Tran1,2, Khoa Anh Luong3, Thinh Phuc Ngo2
1Department of Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, 217 Hong Bang Street, District 5, Ho Chi Minh City, 700000, Vietnam.
Head and neck pathology
|October 16, 2024
概括
侵入性真菌鼻炎 (IFRS) 主要影响老年男性,糖尿病是常见的并发症. 组织病理学有效地区分真菌病原体,如Mucorales和Aspergillus,指导关键的治疗决策.
科学领域:
- 医学真菌学 医学真菌学
- 病理学 病理学 病理学
- 传染性疾病 传染性疾病
背景情况:
- 侵入性真菌鼻炎 (IFRS) 是一种罕见的,高度致命的疾病.
- 关键的病原体包括Mucorales和Aspergillus,需要不同的治疗方法和不同的预后.
研究的目的:
- 阐明IFRS的病理学特征.
- 在IFRS中评估组织病理学在区分真菌病原体中的可靠性.
主要方法:
- 对57个IFRS案例进行了回顾性分析.
- 两个病理学家对H&E,PAS和GMS染色的幻灯片进行了独立的本病理学检查.
- 使用PCR进行真菌鉴定,以组织病理学为指导.
主要成果:
- 国际财务报告准则主要影响男性 (1.4:1比),平均年龄为58.9岁;糖尿病在100%的病例中存在.
- 粘菌 (61.4%) 和Aspergillus (33.3%) 是主要的真菌病原体,没有共同感染.
- 组织病理学和PCR显示出高一致性 (科恩的卡帕=84.2%). 菌病例与非菌病例相比,呈现出更广泛的亡和血管侵袭.
结论:
- 国际财务报告准则 (IFRS) 影响的是年长的男性,通常患有糖尿病.
- 组织病理学是IFRS中Mucorales和Aspergillus区分的一个可靠方法.
- 广泛的亡和血管侵入是区分真菌病原体的关键指标,需要仔细调查.
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