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急性THC对灭绝记忆回忆和恐惧更新的剂量依赖作用:一项随机,双盲,安慰剂控制的随机研究

Nicole L Zabik^1,2,3, Allesandra Iadipaolo³, Craig A Peters³

¹Translational Neuroscience Program, Wayne State University School of Medicine, Tolan Park Medical Building, Detroit, MI, 48201, USA.

Psychopharmacology

|October 16, 2024

概括

低剂量口服的delta-9-tetrahydrocannabinol (THC) 对患有创伤后应激障碍 (PTSD) 的成年人影响恐惧记忆. 剂量和时间对于有效管理恐惧反应和相关的大脑活动至关重要.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
药理学药理学是指药理学的学科.

背景情况:

内分离系统显示出治疗创伤后应激障碍 (PTSD) 中恐惧记忆缺陷的潜力.
以前的研究表明,delta-9-tetrahydrocannabinol (THC) 可以减少PTSD患者的恐惧反应并改变前额叶皮层活动.

研究的目的:

研究THC对PTSD成年人的短期 (24小时) 和长期 (一周) 恐惧学习和记忆的剂量依赖性影响.
为了确定最佳的THC剂量策略,以调节PTSD中的恐惧记忆.

主要方法:

这是一项随机,双盲,安慰剂控制的研究,涉及36名患有PTSD的成年人.
在恐惧灭绝学习之前,参与者接受了安慰剂,5 mg THC 或 10 mg THC.
恐惧回忆和更新被评估24小时和一周后使用行为测量和功能神经成像.

主要成果:

服用后24小时,5毫克THC在恐惧更新期间增加了前 cingulate 和前额叶皮层的激活.
一周后,10毫克THC增强了海马在灭绝回忆期间的激活和在恐惧更新期间的前额叶皮层激活.

结论:

THC的剂量和时间是调节PTSD恐惧记忆过程的关键因素.
在灭绝学习之前服用低剂量口服THC可以影响与恐惧记忆相关的大脑活动,无论是急性还是超过一周.

关键词:

前带带皮层前带带皮层类大麻素是一种大麻素.恐惧是对恐惧进行调节的.在海马体内,海马体创伤后应激障碍 (PTSD) 是一种功能磁力共振成像 (fMRI) 是一种

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