针对老龄化和认知健康 (TEACH) 量身定制教育的干预开发,以预防中年成人痴呆症:随机对照试验的协议
Laura E Korthauer1,2, Rochelle K Rosen3,4, Geoffrey Tremont1
1Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States.
JMIR research protocols
|October 16, 2024
概括
这项研究开发并试验了一种增强的健康教育干预措施,以改善中年痴呆症的预防. 结果将评估这一关键健康行为的变化机制的可行性和初步证据.
科学领域:
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
- 行为科学 行为科学
背景情况:
- 在全球范围内,有12个可修改的风险因素导致40%的痴呆病例,但对预防性健康行为的坚持很低.
- 中年是预防痴呆症的关键时期,因为大脑的变化往往在几十年之前出现症状.
- 虽然多领域干预措施显示出希望,但较低的坚持仍然是一个挑战,与人内因素,如健康信念调解行为变化.
研究的目的:
- 为减少痴呆症风险开发一个增强的健康教育干预措施,包括一种解释方法来传达风险和个人健康信念.
- 试点进行为期8周的随机对照试验,评估与基本健康教育相比,这种增强干预措施的可行性.
主要方法:
- 第1阶段使用混合方法,包括焦点小组 (通过描述性框架矩阵和解释性审查进行分析) 和个人访谈 (使用现象学主题分析编码).
- 第二阶段涉及一项试点随机对照试验,每个手臂有20名参与者.
- 接近的结果,如对阿尔茨海默病的感知威胁,痴呆症意识和自我有效性,在基线,4周和8周被测量.
主要成果:
- 该项目于2022年8月获得资金,数据收集将于2023年开始,预计将于2025年完成.
- 由于数据收集仍在进行中,暂时结果尚未公布.
结论:
- 该研究将确定为期8周的多领域健康教育干预措施的可行性,以预防中年初级痴呆症.
- 这项干预措施的变化机制的初步证据将在研究完成后提供.
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