开发中的脏的感觉和交感内的全面映射
Pierre-Emmanuel Y N'Guetta1, Sarah R McLarnon1, Adrien Tassou2
1Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Cell reports
|October 16, 2024
概括
脏内化始于胚胎发育期间,感官和交感神经纤维与动脉和脏一起生长. 这项研究绘制了精确的时间和神经类型,这些神经发展以控制功能.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 脏生理学 脏生理学
背景情况:
- 脏依赖于来自交感和感觉神经的神经控制来实现平衡.
- 内置的发育过程在很大程度上仍然没有被描述.
研究的目的:
- 为了绘制脏内置的解剖发展图.
- 为了识别发育中的脏神经的神经的类型和起源.
主要方法:
- 光片和共聚焦显微镜用于解剖绘图.
- 免疫组织化学用于识别神经元标记物 (例如,TH+,CGRP+,TRPV1+,PIEZO2+).
- 逆行追踪以确定感官神经元的起源.
主要成果:
- 脏内置开始于胚胎13.5天,与动脉发育保持一致.
- 交感 (TH+) 和感觉 (CGRP+,物质P+,TRPV1+,PIEZO2+) 纤维都刺激脏.
- 感官内置源于背部根结组织T10-L2.2.
- 轴突的生长在产后继续,在人类脏中观察到类似的模式.
结论:
- 这项研究提供了内置发育的全面地图.
- 识别了神经元群体的时间出现和多样性,这些神经元群体内在脏.
- 建立了理解从发育开始对功能神经调节的基础.
关键词:
CP: 发育生物学动脉动脉动脉动脉的动脉.轴子的轴子是一个轴子.发展发展发展发展发展.在内化的时候,内化是内化.脏 脏 脏 脏尼弗朗 (nephron) 是一个名字.神经是神经,神经是神经这是一个感官感官的感觉.这是一个同情的同情.血管系统 血管系统更多相关视频
06:30Quantifying Acute Changes in Renal Sympathetic Nerve Activity in Response to Central Nervous System Manipulations in Anesthetized Rats
Published on: September 11, 2018
7.8K
11:08Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
Published on: February 14, 2018
10.1K
相关概念视频
01:18Blood and Nerve Supply to the Kidney
801
The kidneys are vital organs responsible for filtering and cleaning blood, removing waste products, and regulating electrolyte levels. To perform these essential functions, they require a constant and robust blood supply.
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
Bloody Supply to the Kidneys:
The kidneys receive their blood supply from the renal arteries, which branch off from the abdominal aorta—the main artery supplying the abdomen and lower body. The renal arteries enter the kidneys at the hilum, a notch on the medial side of...
801
01:12Internal Anatomy of the Kidney
1.4K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.4K
01:11Anatomy of the Genitourinary System I: Kidneys and Ureters
2
The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
2
01:28Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
1.2K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.2K
01:21Sympathetic Pathways: Sympathetic Chain Ganglia
2.3K
The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.
The postganglionic neurons of the sympathetic trunk...
The postganglionic neurons of the sympathetic trunk...
2.3K
01:45Kidney Structure
69.0K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
69.0K