用超氧化溶液洗腹腔和伤口对在穿孔性尾炎 (PLaSSo) 开放性尾切除术后手术部位感染的影响:随机临床试验
Harivinthan Sellappan1, Dinesh Alagoo1, Christina Loo1
1Department of Surgery, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia.
BJS open
|October 16, 2024
概括
超氧化溶液在接受开放性尾切除的穿孔性尾炎患者中显著减少了手术部位感染. 这种洗方法在预防术后感染方面优于正常盐水.
科学领域:
- 手术感染控制手术感染控制
- 医疗器械的有效性 医疗器械的有效性
- 临床试验方法论 临床试验方法论
背景情况:
- 穿孔性尾炎的开放性尾切除术后手术部位感染 (SSI) 会导致住院时间增加,成本增加,患者的生活质量降低.
- 随机临床试验 (RCT) 评估超氧化溶液用于穿孔性尾炎是有限的.
- 这项研究旨在评估超氧化溶液洗在预防SSI方面的有效性.
研究的目的:
- 为了确定超氧化溶液洗是否降低了手术部位感染风险.
- 为了比较超氧化溶液与正常盐水在开放的尾切除对于穿孔性尾炎.
主要方法:
- 一个多中心随机临床试验 (RCT) 涉及102名 (13岁以上) 患有穿孔尾炎的患者.
- 在开放性尾切除过程中,患者接受了超氧化溶液或正常盐水,用于腹腔和伤口洗.
- 结果评估了在30天内手术部位感染的情况,对患者,外科医生,评估人员和统计学家进行了失明.
主要成果:
- 超氧化溶液组的整体SSI率明显较低 (15.6%对37.2%;RR0.42) 和表面SSI率 (9.8%对35.3%;RR0.28).
- 需要治疗的数量为四,表明超氧化溶液的有效性.
- 在这两组治疗中都没有报告任何不良事件.
结论:
- 用超氧化溶液洗腹腔和伤口比正常盐水更有效.
- 超氧化溶液洗是预防外科手术部位感染的优质方法,用于接受开放性尾切除手术的穿孔性尾炎患者.
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