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miRNASNP-v4:一个针对17个物种的miRNA相关SNP的综合数据库
Wen Cao1,2, Jiaxin He1, Jing Feng1
1Hubei Hongshan Laboratory, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
Nucleic acids research
|October 16, 2024
概括
更新的miRNASNP数据库 (v4) 现在包括17个物种,提供了关于微RNA (miRNA) 中单核酸多态 (SNP) 和它们的标的广泛数据. 该资源有助于理解多种物种的疾病机制和miRNA功能.
科学领域:
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
- 分子生物学分子生物学
背景情况:
- 微RNA (miRNA) 中的单核酸多态 (SNP) 和它们的标结合位影响miRNA生物发生和调节,影响各种疾病.
- 现有的miRNA-SNP数据库受到物种覆盖范围和数据最新性的限制.
研究的目的:
- 将miRNASNP数据库更新和扩展到第4版本,以提高其用于研究miRNA相关SNP的实用性.
- 为影响miRNA活动的SNP的功能分析提供全面的多种资源.
主要方法:
- 在17个物种中对miRNA和3'-非翻译区域 (3'UTR) SNPs进行数据编制和更新.
- 鉴定SNP对miRNA二次结构和标结合亲和力的潜在影响的描述.
- 对人类癌症进行基因丰富分析,药物反应和免疫透关联研究的整合.
主要成果:
- 在17个物种中确定了miRNA中的82,580个SNP和3'UTR基因中的24,836,179个SNP.
- miRNASNP-v4包括新的功能,如基因丰富分析,识别与癌症相关的miRNA-SNPs,并包括实验验证的免疫相关miRNAs.
- 开发了17种动物物种的在线预测工具,扩大了数据库的适用性.
结论:
- miRNASNP-v4与之前的版本相比,是一个显著的进步,提供了广泛的,更新的数据和新的功能.
- 该数据库是研究人员研究SNP和miRNA在各种生物环境和疾病中的功能作用的宝贵,用户友好的资源.
- 扩大了物种覆盖范围和分析工具,促进了跨物种的比较研究和药物发现工作.
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