抗凝剂治疗可能会降低Behcet病肺动脉参与的复发率.
Kerem Yiğit Abacar1, Ayşe Elif Boncukcuoglu2, Aysun Aksoy3
1From the Division of Rheumatology, Department of Internal Medicine, School of Medicine, Marmara University, Istanbul, Turkey.
概括
在贝希特病 (Behçet's disease,BD) 中,肺动脉的干扰主要呈现为血栓形成. 在免疫抑制治疗中添加抗凝剂显著降低了肺动脉干扰的BD患者的复发风险.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
背景情况:
- 肺动脉干扰 (PAI) 是贝塞特病 (BD) 死亡的一个关键原因.
- 了解BD中PAI的临床谱和复发因素对于患者管理至关重要.
研究的目的:
- 为了研究与贝切特病相关的肺动脉干扰患者的临床特征,疾病过程和复发风险因素.
- 为了确定BD相关的PAI复发的预测因素.
主要方法:
- 从1990年到2023年期间接受治疗的贝塞特病患者的医疗记录的回顾性分析.
- 肺动脉干扰的分类为血栓形成或动脉瘤.
- 多变量考克斯回归分析以确定影响复发风险的因素.
主要成果:
- 在1350名BD患者中,110名 (8.1%) 患有PAI. 肺动脉血栓发生在94.5%的病例中,而动脉瘤是罕见的 (6.6%).
- 无症状的PAI患者更年轻,而有症状的患者的女性性别和复发率更高.
- 大约28.2%的患者经历了至少一次PAI复发;不启动抗凝剂独立增加了复发风险 (HR,4.36).
结论:
- 肺动脉血栓形成是BD中PAI的主要表现,动脉瘤不常见.
- 尽管接受了免疫抑制疗法,但很大一部分患者 (约三分之一) 经历了复发.
- 抗凝剂治疗,当与免疫抑制治疗相结合时,在患有PAI的BD患者中大幅降低了复发率.
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