在肺癌中,miRNA-21是一种调节细胞增殖,迁移,入侵和治疗反应的oncomiR
Roberta Queiroz da Silvia Lima1, César Freire Melo Vasconcelos2, João Pedro Alves Gomes1
1Research Center for Therapeutic Innovation Suely Galdino, Federal University of Pernambuco, Recife, Brazil.
Pathology, research and practice
|October 16, 2024
概括
微RNA-21 (miRNA-21) 在肺癌的发展中起着关键作用,影响诸如瘤发生和转移等过程. 了解miRNA-21路径可以改善肺癌的早期检测和患者预后.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 肺癌是全球癌症死亡的主要原因,通常是晚期诊断,导致生存率低下.
- 目前的诊断方法,如活检,通常在疾病进展晚期进行.
- 微RNA-21 (miRNA-21) 与包括肺癌在内的各种癌症有关,这表明它在疾病机制中的潜在作用.
研究的目的:
- 审查和综合目前关于miRNA-21在肺癌细胞过程中的作用的知识.
- 探索miRNA-21在瘤发生,转移和治疗耐药性的参与.
- 评估miRNA-21在肺癌中的诊断和预后意义.
主要方法:
- 通过使用PubMed,Scielo和ClinicalTrials.gov.gov等数据库进行了广泛的文献审查.
- 精选的文章重点关注miRNA-21调制通路,相关基因和肺癌中的蛋白质.
- 研究包括体外,体内和临床试验数据.
主要成果:
- 37篇相关论文从3294篇已识别的文章中被选中.
- miRNA-21对关键的信号通路产生影响,这些通路对肺癌的发展至关重要.
- 很大一部分研究涉及体外 (57%) 和体内 (22%) 评估,确定了12项临床试验.
结论:
- miRNA-21是肺癌发展的关键因素,影响多个细胞过程.
- 准miRNA-21通路有可能改善肺癌诊断和患者预后.
- 进一步的研究可以促进将miRNA-21的实验结果转化为肺癌管理的临床应用.
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