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通过综合基因型和表型分析,在环境多媒体接口上的抗生素耐药性

Chen-Xi Fu¹, Chen Chen², Qian Xiang³

¹State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, China; Institute of Environment, Resource, Soil and Fertilizer, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.

Journal of hazardous materials

|October 16, 2024

概括

环境界面,如塑料污染的环境界面,显著增加了活跃的抗生素耐药细菌. 这项研究揭示了在这些关键的环境界面上丰富的抗生素耐药性基因 (ARG) 和移动遗传元素 (MGE).

科学领域:

环境科学环境科学
微生物学微生物学
环境化学环境化学

背景情况:

抗生素耐药性是全球卫生危机.
抗生素耐药性基因 (ARG) 在环境中普遍存在.
在环境界面的抗生素耐药性仍然不太了解.

研究的目的:

调查环境界面上的抗生素耐药性,特别是在带有塑料污染的土中.
为了比较单个与多个环境介质中的抗生素耐药性.
确定影响ARG和移动遗传元素 (MGE) 丰富的因素.

主要方法:

一个微观的研究模拟了在田土壤中的塑料污染.
刺激拉曼散射与二氧化 (D2O) 标签相结合,以检测活性细菌.
基因型分析以确定ARG和MGE.

主要成果:

涉及更多环境介质的接口显示出更高比例的活性耐药细菌.
在环境界面上,ARG和MGE显著丰富.
重金属 () 和抗生素 () 的共同压力进一步增强了ARG/MGE的丰富.

结论:

环境界面,特别是那些有塑料污染的界面,是抗生素耐药性的热点.
这项研究突出了ARG传播的新途径.
与环境接口相关的被忽视的人类健康风险需要进一步调查.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.多媒体接口接口.现型性耐药性现型性耐药性现型性耐药性耐药细菌是一种耐药性的细菌.刺激了拉曼散射的作用.

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