母亲的特征影响胎儿性别和叠加的孕前之间的关系

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Akaninyene I Noah¹, Camillia R Comeaux², Ashley V Hill³

¹Advocate Aurora Research Institute, Milwaukee, WI, USA.

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|October 16, 2024

概括

女性胎儿的性别与在母亲的晚年,肥胖或以前分娩的母亲中叠加妊娠前的风险更高. 这表明胎儿的性别可能与妊娠并发症中的母亲因素相互作用.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
生殖健康生殖健康

背景情况:

关于女性胎儿性别与早产子前之间的关联存在不一致的发现.
妊娠高血压障碍 (HDP) 对母亲和胎儿的健康构成重大风险.

研究的目的:

研究胎儿性别与各种妊娠高血压疾病 (HDP) 之间的关系.
确定母体特征是否会改变女性胎儿性别与HDP风险之间的关联.

主要方法:

对43,737个单独怀孕的回顾性队列研究.
修改Poisson回归被用于计算调整的相对风险 (RR) 和95%置信区间 (CI).
相互作用分析检查了母亲因素和女性胎儿性别对HDP风险的相互作用.

主要成果:

雌性胎儿性别与叠加的孕前 (aRR 1.13,95% CI 1.00-1.28) 有边际关联.
发现女性胎儿性别与晚年母亲年龄,肥胖和性别平等之间存在显著的相互作用.
在女性胎儿和晚年母亲年龄 (aRR 1.29,95% CI 1.05-1.58),平价 (aR 1.15,95% CI 1.00-1.34) 和肥胖 (aRR 1.27,95% CI 1.03-1.35) 的个体中,观察到叠加孕前的风险增加.

结论:

雌性胎儿可能会根据母亲的特征不同地影响叠加孕前的风险.
这些发现突出了胎儿性别和孕产妇因素在妊娠高血压疾病发展中的潜在相互作用.

关键词:

高血压疾病高血压疾病孕前症孕前症性差异的性别差异

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