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Updated: Jun 10, 2025

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Ex Vivo Porcine Experimental Model for Studying and Teaching Lung Mechanics

Published on: April 19, 2024

在机械通风系统下,COVID-19对肺功能影响的个性化计算模型

Jason M Carson¹, Raoul Van Loon¹, Hari Arora¹

¹Department of Biomedical Engineering, Faculty of Science and Engineering, Swansea University, Bay Campus, Fabian Way, Swansea, SA1 8EN, Wales, UK.

Computers in biology and medicine

|October 16, 2024

概括

这项研究模拟了机械通风COVID-19患者的肺机制,揭示了竞争性肺损伤类型如何影响空气流和压力. 这种特定于患者的方法有助于关键呼吸系统护理和疾病研究.

科学领域:

医学成像和计算流体动力学
呼吸系统机制呼吸系统机制
COVID-19的病理生理学

背景情况:

机械通风对于严重的COVID-19患者至关重要.
了解肺机械对于优化通风策略至关重要.
在COVID-19中异质的肺损伤使气流和压力分布复杂化.

研究的目的:

开发和验证用于分析肺气流和气压的计算建模框架.
调查异质性肺病态对COVID-19中呼吸机制的影响.
模拟患者特定的肺部状况,以改善重症监护.

主要方法:

从CT图像中细分肺气道和腹膜.
创建一个针对患者的二分式气道网络.
使用霍恩斯菲尔德单位估计区域肺抵抗和遵守.
计算流体动力学 (CFD) 的应用用于模拟流量和压力分布.

主要成果:

模拟显示,由于纤维化和肺等竞争性病理,肺流分布发生了显著的变化.
纤维化样损伤增加了区域性耐药性,并降低了服从性.
疹状病症降低了抵抗力和增加了服从,导致潜在的过度通货膨胀 (严重病例预计增加33%).
模型预测了膜断裂的风险增加在缩性区域.

结论:

开发的框架有效地模拟了机械通风COVID-19患者的肺机械.
异质性肺损伤显著影响空气流和压力,影响通风策略.
患者特定的建模可以指导临界呼吸系统护理的早期干预.
该框架可适应研究其他呼吸道疾病.

关键词:

在 COVID-19 疫情中,计算流体动力学的流体动力学.肺部建模肺部建模机械通风机械通风机械通风机减少订单建模减少订单建模

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