纳米粒子比其他来源更好地影响后代的肠道健康
Yanhong Chen1, Sasa Zhang2, Xuyang Gao1
1State Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Poultry science
|October 16, 2024
概括
纳米颗粒 (Nano-Se) 的孕产妇饮食改善了的后代存活率和骨发育. 通过调节关键细胞通路,纳米-Se增强了肠道结构,抗氧化能力和杯状细胞功能.
科学领域:
- 动物营养和生理学
- 禽畜科学 禽畜科学 禽畜科学
- 微量矿物质的新陈代谢
背景情况:
- (Se) 是一种重要的微量元素,对动物健康和免疫功能至关重要.
- 不同的来源 (纳米颗粒,单氨酸,单氨酸,单氨酸,单) 的生物可用性和有效性各不相同.
- 母亲的营养显著影响后代的发育,特别是肠道健康和生存.
研究的目的:
- 评估不同母性食源对后代尾粘膜功能的影响.
- 为了比较纳米颗粒 (Nano-Se) 与其他常见的补充剂的疗效.
- 研究对后代生存,肠道形态,细胞分化和炎症通路的影响.
主要方法:
- 总共630只和70只公被食Se-贫乏饮食,随后补充各种Se来源 (纳米Se,单半氨酸,单,单氨酸) 或对照饮食8周.
- 来自胚胎和新的小的体组织被分析为形态参数 (体高度,密室深度),细胞计数 (杯细胞) 和基因表达 (紧密的结节,细胞分化标志物,细胞亡,NLRP3通路).
- 在化后7天记录了后代的生存率.
主要成果:
- 补充0.30毫克/千克纳米-Se,单半氨酸或单氨酸的孕产妇饮食显著增加了7天后代的存活率.
- 0.30毫克/公斤Nano-Se显著增强了后代的阴毛高度,毛高度/密室深度比,杯状细胞数量和粘素表达 (Muc2,Spdef,C-myc).
- 纳米-Se补充剂减少了活性氧物种,降低了与亡相关的基因表达,并降低了1天大的小的NLRP3炎症酶通路的调节.
结论:
- 母亲的食纳米-Se补充剂在改善小骨微型架构,抗氧化状态和后代的紧密结合蛋白表达方面优越.
- 纳米-Se有效地支持杯细胞发育和肠道屏障功能,可能通过抑制NLRP3信号通路.
- 纳米粒子是提高家禽肠道健康和后代活力的高效来源.
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