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Updated: Jun 10, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
07:23

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向外体双链RNA-TLR3信号通路减弱了吗啡耐受性和过敏症

Bing Wang1, Dong-Sheng Le2, Li Liu2

  • 1Department of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, USA; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, Jiangsu, China.

Cell reports. Medicine
|October 16, 2024
PubMed
概括

长期使用吗啡会增加脊髓双链RNA (dsRNA),导致疼痛过敏. 通过ADAR1减少dsRNA或阻止其释放可以防止这种情况,提供新的疼痛管理策略.

关键词:
在 ADAR1 中,ADAR1 是在TLR3中,它是TLR3.这是一种双链RNA.微质细胞中的微质细胞这是吗啡吗啡.

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