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Updated: May 6, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
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使用纽约市C型肝炎计划和监测数据验证基于实验室的简化HCV清除定义

Christina S Hwang1, Martha P Montgomery, Diana I Diaz Munoz

  • 1Author Affiliations: Bureau of Hepatitis, HIV and STI, New York City Department of Health and Mental Hygiene, New York City, New York (Mss Hwang, Diaz Munoz, and Bocour); and National Center for HIV, Viral Hepatitis, STD, and TB Prevention at US Centers for Disease Control and Prevention, Atlanta, Georgia (Drs Montgomery, Yin, and Teshale).

Journal of public health management and practice : JPHMP
|October 16, 2024
PubMed
概括

一个验证的C型肝炎病毒 (HCV) 清除的实验室定义显示了与临床治疗的高度一致. 这一发现支持使用公共卫生监测数据来监测HCV消除进展.

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Hepatic Drug Clearance: Restrictive and Nonrestrictive Clearance

Hepatic clearance refers to the volume of blood cleared of a drug by the liver per unit of time. It plays a crucial role in drug metabolism and elimination. While hepatic clearance is commonly estimated by subtracting renal clearance from total body clearance, other pathways, such as pulmonary or biliary clearance, may also contribute. However, these pathways are generally less significant than hepatic and renal clearance.
Most drugs undergo restrictive clearance, which is proportional to the...
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