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将FOXA1的开拓性功能与共价小分子重定向

Sang Joon Won1, Yuxiang Zhang1, Christopher J Reinhardt1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

Molecular cell
|October 16, 2024
PubMed
概括

研究人员发现了化学修改先驱转录因子 (TF) 的小分子,如FOXA1,改变它们在癌细胞中的DNA结合和染色质重塑活性.

关键词:
ATAC-seqq 的使用情况.在 ChIP-seqq.我们的FOXA1A1基于活动的蛋白质分析.在这种情况下,染色染色素它们是共价的.半氨酸 (cysteine) 是一种氨酸.开拓者的转录因子蛋白质组学 蛋白质组学

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