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Updated: Jun 10, 2025

Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Published on: November 5, 2019

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根据瘤DNA测序数据重建瘤克隆异质性和进化关系

Zhen Wang1,2, Yanhua Fang3, Ruoyu Wang1

  • 1The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning, China.

Briefings in bioinformatics
|October 16, 2024
PubMed
概括

这项研究引入了RETCHER,这是一种用于重建瘤克隆异质性和进化关系的新型计算方法. 雷切尔精确地识别了突变多重性和遗传学关系,改善了瘤进化研究和个性化治疗策略.

关键词:
大量的DNA测序.克隆异质性的异质性进化 演化 演化 演化 演化 演化 演化 演化突变的多重性 突变的多重性瘤是一个瘤.

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