假肢关节感染抑制性抗菌治疗的全球实践变化:一个横截面调查研究
Jaap L J Hanssen1, Maaike G J Gademan2, Marjan Wouthuyzen-Bakker3
1Leiden University Center for Infectious Diseases (LU-CID), Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands.
The Journal of infection
|October 16, 2024
概括
对假肢关节感染 (PJI) 进行抑制性抗菌疗法 (SAT) 的全球使用因地区而异. 在SAT的指示,药物选择,剂量或PJI管理的持续时间方面没有全球共识.
科学领域:
- 传染性疾病 传染性疾病
- 整形外科手术 整形外科手术
- 抗微生物药物管理委员会
背景情况:
- 假肢关节感染 (PJI) 管理通常涉及复杂的抗菌药物策略.
- 抑制性抗菌疗法 (SAT) 是PJI治疗中使用的一种方法.
- 了解SAT实践的全球变化对于优化患者护理至关重要.
研究的目的:
- 调查和确定抑制性抗微生物疗法 (SAT) 在假肢关节感染 (PJI) 的临床应用中的地理差异.
- 探索世界各地的PJI中SAT的指示,药物选择,剂量,治疗持续时间和随访协议的变化.
主要方法:
- 一项国际在线调查分发给传染病专家和骨科外科医生.
- 该调查收集了临床医生对PJI管理的SAT方法的数据.
- 受访者代表43个国家,回答率为20%.
主要成果:
- 在脱bridement,抗生素和植入物保留 (DAIR) 或单阶段修订后启动SAT时,观察到显著的区域差异.
- 对于葡萄球菌PJI的首选SAT疗法在北美,欧洲和大洋洲之间有很大的差异.
- 没有确定Gram-阴性PJI中SAT的一致的全球或区域偏好,并且SAT的剂量和持续时间存在相当大的差异.
结论:
- 对于假肢关节感染 (PJI) 的抑制性抗菌疗法 (SAT) 的方法是高度区域性的.
- 对于PJI的SAT的指示,选择,剂量和持续时间缺乏全球共识.
- 需要进一步进行高质量的研究,以建立PJI治疗的最佳SAT策略.
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