相关实验视频

Updated: Jun 23, 2026

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Prevention of Heat Stress Adverse Effects in Rats by Bacillus subtilis Strain

Published on: July 11, 2016

乳酸细菌补充:一种生物保护方法,用于减轻诱导的毒性,并在小鼠模型中调节基因表达

Nadia Beheshtian¹, Ehsan Karimi¹, Ehsan Oskoueian²

¹Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

|October 16, 2024

概括

某些乳酸细菌菌株,LeviLactobacillus brevis (AC10) 和Lacticaseibacillus rhamnosus (AC11),通过减少氧化应激和改善健康标志物,有效地减轻小鼠中的毒性.

科学领域:

微生物学微生物学
毒理学毒理学毒理学
营养科学营养科学

背景情况:

暴露会导致氧化应激,炎症和器官损伤.
乳酸细菌 (LAB) 以其健康益处和抵消毒性的潜力而闻名.
特定的LAB菌株可能具有用于重金属排毒的独特特性.

研究的目的:

评估LeviLactobacillus brevis (AC10),Lacticaseibacillus rhamnosus (AC11) 和Pediococcus acidilactici (AC15) 在小鼠中对诱导的毒性的疗效.
研究这些LAB菌株对氧化应激标志物,器官功能和基因表达的影响.
为了确定测试LAB菌株的重金属吸收能力.

主要方法:

鼠被暴露在中,然后用不同的LAB菌株治疗.
评估的参数包括体重,食物摄入量,肝酶,抗氧化酶,免疫球蛋白水平,脂质过氧化和肝脏和大脑中的基因表达.
在实验室中对LAB菌株的吸收进行了评估,并在体内分析了它们的影响.

主要成果:

与AC15相比,AC10和AC11菌株的吸收能力优于AC15.
双重补充AC10和AC11显著改善了体重,食物摄入量,并减少了沉积.
益生菌治疗增强了抗氧化潜力,抑制了炎症,并在暴露于的小鼠中改善了直肠形态.

结论:

莱维Lactobacillus brevis (AC10) 和Lacticaseibacillus rhamnosus (AC11) 显示出对毒性的显著保护作用.
这些益生菌通过包括重金属封存,抗氧化剂增强和维护肠道完整性的机制来抵消引起的损伤.
饮食补充AC10和AC11是一种有希望的策略,可以减轻暴露对健康的不良影响.

关键词:

生物解毒的方法是生物解毒.生物保护生物保护生物修复是一种生物修复.沉重金属的封存方式益生菌益生菌益生菌

更多相关视频

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation

Published on: July 27, 2022

相关概念视频

Microbiota Modulation by Antibiotics

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...